Opening book details…
Can I read Candida albicans and Enterococcus faecalis biofilm frenemies: When the relationship sours on EtoBox?
Candida albicans and Enterococcus faecalis biofilm frenemies: When the relationship sours by Om Alkhir Alshanta; Khawlah Albashaireh; Emily McKloud; Christopher Delaney; Ryan Kean; William McLean; Gordon Ramage is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Candida albicans and Enterococcus faecalis biofilm frenemies: When the relationship sours about?
The opportunistic yeast __Candida albicans__ and lactic acid bacteria __Enterococcus faecalis__ are frequently co-isolated from various infection sites on the human body, suggesting a common interkingdom interaction. While some reports suggest an antagonism, the reason for their co-isolation therefore remains unclear. The purpose of this study was to undertake a detailed characterisation of this dual-species interaction. We used standard biofilm characterisation methodologies alongside an RNASeq analysis to assess the response of __C. albicans__ to __E. faecalis.__ We evaluated the relevance of pH to dual-species biofilm interactions and demonstrated that __E. faecalis__ rapidly and significantly impacted __C. albicans__ morphogenesis and biofilm formation, which was mirrored by levels of gene expression. These transcripts were enriched in amino acids biosynthesis and metabolism pathways in co-cultures, a finding that guided our investigation into pH related mechanism. We were able to demonstrate the direct role of __E. faecalis__ induced low pH, which inhibited __C. albicans__ hyphal morphogenesis and biofilm formation. The results suggest that the anti-candidal effect of __E. fae
Who reads Candida albicans and Enterococcus faecalis biofilm frenemies: When the relationship sours?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Om Alkhir Alshanta; Khawlah Albashaireh; Emily McKloud; Christopher Delaney; Ryan Kean; William McLean; Gordon Ramage
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)