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Content and Traffic of Taurine in Hippocampal Reactive Astrocytes by Fèlix Junyent; Luisa De Lemos; Juana Utrera; Sonia Paco; Fernando Aguado; Antoni Camins; Mercè Pallàs; Rafael Romero; Carme Auladell is a Neuroscience article available to read on EtoBox.

What is Content and Traffic of Taurine in Hippocampal Reactive Astrocytes about?

## Abstract Taurine is one of the most abundant free amino acids in the mammalian central nervous system, where it is crucial to proper development. Moreover, taurine acts as a neuroprotectant in various diseases; in epilepsy, for example, it has the capacity to reduce or abolish seizures. In the present study, taurine levels has been determine in mice treated with Kainic Acid (KA) and results showed an increase of this amino acid in hippocampus but not in whole brain after 3 and 7 days of KA treatment. This increase occurs when gliosis was observed. Moreover, taurine transporter (TAUT) was found in astrocytes 3 and 7 days after KA treatment, together with an increase in __cysteine sulfinic acid decarboxylase__ (__csd__) mRNA, that codifies for the rate‐limiting enzyme of taurine synthesis, in the hippocampus at the same times after KA treatment. Glial cultures enriched in astrocytes were developed to demonstrate that these cells are responsible for changes in taurine levels after an injury to the brain. The cultures were treated with proinflammatory cytokines to reproduce gliosis. In this experimental model, an increase in the immunoreactivity of GFAP was observed, together with a

Who reads Content and Traffic of Taurine in Hippocampal Reactive Astrocytes?

Author

Fèlix Junyent; Luisa De Lemos; Juana Utrera; Sonia Paco; Fernando Aguado; Antoni Camins; Mercè Pallàs; Rafael Romero; Carme Auladell

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)