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Genome-wide discovery, and computational and transcriptional characterization of an AIG gene family in the freshwater snail Biomphalaria glabrata, a vector for Schistosoma mansoni by Lu, Lijun; Loker, Eric S.; Zhang, Si-Ming; Buddenborg, Sarah K.; Bu, Lijing is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background The AIG (avrRpt2-induced gene) family of GTPases, characterized by the presence of a distinctive AIG1 domain, is mysterious in having a peculiar phylogenetic distribution, a predilection for undergoing expansion and loss, and an uncertain functional role, especially in invertebrates. AIGs are frequently represented as GIMAPs (GTPase of the immunity associated protein family), characterized by presence of the AIG1 domain along with coiled-coil domains. Here we provide an overview of the remarkably expanded AIG repertoire of the freshwater gastropod __Biomphalaria glabrata__, compare it with AIGs in other organisms, and detail patterns of expression in __B. glabrata__ susceptible or resistant to infection with __Schistosoma mansoni__, responsible for the neglected tropical disease of intestinal schistosomiasis. ## Results We define the 7 conserved motifs that comprise the AIG1 domain in __B. glabrata__ and detail its association with at least 7 other domains, indicative of functional versatility of __B. glabrata__ AIGs. AIG genes were usually found in tandem arrays in the __B. glabrata__ genome, suggestive of an origin by segmental gene duplication. We found 91 genes wi

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Author

Lu, Lijun; Loker, Eric S.; Zhang, Si-Ming; Buddenborg, Sarah K.; Bu, Lijing

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2164)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)