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Extracellular Matrix Mimicking Nanofibrous Scaffolds Modified With Mesenchymal Stem Cell-Derived Extracellular Vesicles for Improved Vascularization by Dake Hao; Hila Shimshi Swindell; Lalithasri Ramasubramanian; Ruiwu Liu; Kit S. Lam; Diana L. Farmer; Aijun Wang is a Engineering article available to read on EtoBox.
The network structure and biological components of natural extracellular matrix (ECM) are indispensable for promoting tissue regeneration. Electrospun nanofibrous scaffolds have been widely used in regenerative medicine to provide structural support for cell growth and tissue regeneration due to their natural ECM mimicking architecture, however, they lack biological functions. Extracellular vesicles (EVs) are potent vehicles of intercellular communication due to their ability to transfer RNAs, proteins, and lipids, thereby mediating significant biological functions in different biological systems. Matrix-bound nanovesicles (MBVs) are identified as an integral and functional component of ECM bioscaffolds mediating significant regenerative functions. Therefore, to engineer EVs modified electrospun scaffolds, mimicking the structure of the natural EV-ECM complex and the physiological interactions between the ECM and EVs, will be attractive and promising in tissue regeneration. Previously, using one-bead one-compound (OBOC) combinatorial technology, we identified LLP2A, an integrin α4β1 ligand, which had a strong binding to human placenta-derived mesenchymal stem cells (PMSCs). In this
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- Author
- Dake Hao; Hila Shimshi Swindell; Lalithasri Ramasubramanian; Ruiwu Liu; Kit S. Lam; Diana L. Farmer; Aijun Wang
- Publisher
- Frontiers Media SA
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)