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Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis by D K Petkova; C A Clelland; J E Ronan; S Lewis; A J Knox is a Medicine article available to read on EtoBox.

What is Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis about?

**Aims:** To test the hypothesis that cyclooxygenase (COX)‐1 or COX‐2 expression is defective in lungs in idiopathic pulmonary fibrosis (IPF) and to characterize the cellular distribution. IPF is a progressive inflammatory lung disorder with an adverse prognosis. Previous work has shown that prostaglandin E~2~ (PGE~2~) regulates collagen deposition and fibroblast proliferation and a defect in COX regulation may contribute to the fibrosis that occurs in IPF. **Methods:** Immunohistochemistry was utilized to determine COX immunoreactivity in lung sections from 25 IPF, six sarcoidosis and 14 control subjects. **Results:** COX‐1 and COX‐2 expression in bronchiolar epithelial cells was significantly lower in IPF and sarcoidosis than in controls. No significant difference was found in COX‐2 expression between macrophages in IPF and control sections, but COX‐2 was reduced in macrophages in sarcoidosis compared with controls. **Conclusions:** These studies confirm COX‐2 loss in bronchial epithelial cells but not macrophages in IPF, and show for the first time reduced constitutive COX‐1 expression in epithelial cells and macrophages. Similar abnormalities were observed in sarcoidosis.

Who reads Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis?

Author

D K Petkova; C A Clelland; J E Ronan; S Lewis; A J Knox

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0309-0167)

Published

2003

Language

EN

Field

Medicine (Health Sciences)