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What is GDF-5 Induces Apoptosis in B Cells about?

1. The study examined the effects of growth/differentiation factor-5 (GDF-5) on mouse B cell hybridoma HS-72 cells. 2. The results showed that GDF-5 induced cell cycle arrest in the G1 phase before apoptosis occurred in the HS-72 cells. 3. The overexpression of Smad6 and Smad7 in HS-72 cells suppressed the GDF-5-induced G1 cell cycle arrest and apoptosis by inhibiting the expression of p21CIP-1/WAF-1 and hypophosphorylation of retinoblastoma protein.

Author

rolla_hira

Language

EN