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ProANP31-67 ameliorates adverse cardiac remodeling and improves systolic and diastolic functions in a preclinical model of cardiorenal syndrome by GJJ Silva; R Parvan; X Shen; M Frisk; R Altara; ME Strand; KB Rypdal; IG Lunde; WE Louch; JM Aronsen; K-O Stenslokken; MK Stokke; A Cataliotti is a Medicine article available to read on EtoBox.

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## Abstract ## Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): South-Eastern Norway Regional Health Authority (HSØ-RHF, Project No. 25674) ## Background The cardiac hormone proANP31-67, a linear fragment of the N-terminal Atrial Natriuretic Peptide, has known enhancing renal effects. More recently, we described the cardio protective effects of this hormone in a model of chronic hypertension. More specifically, independently of the blood pressure level, proANP31-67 improved diastolic function, attenuated cardiac fibrosis, and reduced hypertrophy. ## Purpose The current study was designed to assess the cardiorenal effects of proANP31-67 in a rodent model of hampered renal function, followed by cardiac injury produced by ischemia/reperfusion (I/R). ## Methods Right uninephrectomy (UNX) was performed in Wistar rats (n=28). Sixteen weeks after UNX, rats underwent cardiac I/R injury and randomly assigned to proANP31-67 (50 ng/kg/day s.c., n=15) or Vehicle (n=13) for four weeks post I/R. Echocardiographic examinations were performed at baseline (before UNX), 16 weeks after UNX, and four weeks after I/R. At the end of the st

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Author

GJJ Silva; R Parvan; X Shen; M Frisk; R Altara; ME Strand; KB Rypdal; IG Lunde; WE Louch; JM Aronsen; K-O Stenslokken; MK Stokke; A Cataliotti

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)