About this Neuroscience article

Reduced Glutamate Immunolabeling in the Nucleus Accumbens Following Extended Withdrawal from Self-administered Cocaine by Alan S. Keys; Gregory P. Mark; Nil Emre; Charles K. Meshul is a Neuroscience article available to read on EtoBox.

Alterations in the density of GABA and glutamate immunolabeling within nerve terminals in the shell region of the nucleus accumbens were assessed in rats withdrawn from intravenous cocaine exposure. Four groups of rats were used: one group self-administered cocaine (0.42 mg/kg/infusion) in daily 3-h sessions for approximately 2 weeks, two additional groups received either saline or cocaine in a noncontingent fashion, and a fourth comprised a drug-naive, age-matched control group. Immunogold electron microscopy was used to quantify presynaptic terminal GABA and glutamate density within the vesicular and mitochondrial pools approximately 18 days following the last drug or saline exposure in the treatment groups. A significant 27.7% decrease in vesicular glutamate density within asymmetrical nerve terminals was observed in animals that self-administered cocaine as compared to controls. This group also showed an 18.6% decrease in vesicular nerve terminal glutamate immunolabeling as compared to animals that were administered a similar total dose of cocaine in a responseindependent fashion. No significant changes in the density of nerve terminal GABA vesicular immunolabeling were observe

Author

Alan S. Keys; Gregory P. Mark; Nil Emre; Charles K. Meshul

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)