Can I read Treatment of Retinoblastoma: What Is the Latest and What Is the Future on EtoBox?

Treatment of Retinoblastoma: What Is the Latest and What Is the Future by Paula Schaiquevich; Jasmine H. Francis; María Belén Cancela; Angel Montero Carcaboso; Guillermo L. Chantada; David H. Abramson is a Medicine article available to read on EtoBox.

What is Treatment of Retinoblastoma: What Is the Latest and What Is the Future about?

The management of retinoblastoma, the most common intraocular malignancy in children, has changed drastically over the last decade. Landmark developments in local drug delivery, namely, safer techniques for intravitreal chemotherapy injection and ophthalmic artery chemosurgery, have resulted in eye globe salvages that were not previously attainable using systemic chemotherapy or external beam irradiation. Novel drugs, oncolytic viruses, and immunotherapy are promising approaches in the treatment of intraocular retinoblastoma. Importantly, emerging studies of the pattern of tumor dissemination and local drug delivery may provide the first steps toward new treatments for metastatic disease. Here, we review recent advances in retinoblastoma treatment, especially with regard to local drug delivery, that have enabled successful conservative management of intraocular retinoblastoma. We also review emerging data from preclinical and clinical studies on innovative approaches that promise to lead to further improvement in outcomes, namely, the mechanisms and potential uses of new and repurposed drugs and non-chemotherapy treatments, and discuss future directions for therapeutic development.

Who reads Treatment of Retinoblastoma: What Is the Latest and What Is the Future?

Author

Paula Schaiquevich; Jasmine H. Francis; María Belén Cancela; Angel Montero Carcaboso; Guillermo L. Chantada; David H. Abramson

Publisher

Frontiers Media SA

Published

2022

Language

EN

Field

Medicine (Health Sciences)