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Can I read Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers on EtoBox?
Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers by Ismail Ben Mosbah; Marta Massip-Salcedo; Izabel Fernández-Monteiro; Carme Xaus; Ramon Bartrons; Olivier Boillot; Joan Roselló-Catafau; Carmen Peralta is a Medicine article available to read on EtoBox.
What is Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers about?
This study investigates how the addition of trimetazidine (TMZ) and aminoimidazole-4-carboxamide ribonucleoside (AICAR) to University of Wisconsin (UW) solution protects steatotic livers. Steatotic and nonsteatotic livers were preserved for 24 hours at 4°C in UW and UW with TMZ and AICAR (separately or in combination) and then perfused ex vivo for 2 hours at 37°C. Adenosine monophosphate-activated protein kinase (AMPK) or nitric oxide (NO) synthesis inhibition in livers preserved in UW with TMZ was also investigated. Hepatic injury and function (transaminases, bile production, and sulfobromophthalein clearance) and factors potentially involved in the susceptibility of steatotic livers to ischemia-reperfusion (I/R), including vascular resistance, mitochondrial damage, adenosine triphosphate depletion, and oxidative stress were evaluated. AMPK, NO synthase (NOS), nitrate, and nitrite levels were also determined. The addition of TMZ and AICAR (separately or in combination) to UW reduced hepatic injury, improved functionality, and protected against the mechanisms responsible for the vulnerability of steatotic livers to I/R. Like AICAR, TMZ increased AMPK, constitutive NOS, and nitrates
Who reads Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers?
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- Author
- Ismail Ben Mosbah; Marta Massip-Salcedo; Izabel Fernández-Monteiro; Carme Xaus; Ramon Bartrons; Olivier Boillot; Joan Roselló-Catafau; Carmen Peralta
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)