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Proteomics and Phosphoproteomics for the Mapping of Cellular Signalling Networks by Christian Preisinger; Alex von Kriegsheim; David Matallanas; Walter Kolch is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Proteomics and Phosphoproteomics for the Mapping of Cellular Signalling Networks about?

## Abstract Proteomics is transitioning from inventory mapping to the mapping of functional cellular contexts. This has been enabled by progress in technologies as well as conceptual strategies. Here, we review recent advances in this area with focus on cellular signalling pathways. We discuss genetics‐based methods such as yeast two hybrid methods as well as biochemistry‐based methods such as two‐dimensional gel electrophoresis, quantitative proteomics, interaction proteomics, and phosphoproteomics. A central tenet is that by its ability to capture dynamic changes in protein expression, localisation and modification modern proteomics has become a powerful tool to map signal transduction pathways and deliver the functional information that will promote insights in cell biology and systems biology.

Who reads Proteomics and Phosphoproteomics for the Mapping of Cellular Signalling Networks?

Author

Christian Preisinger; Alex von Kriegsheim; David Matallanas; Walter Kolch

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)