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Longitudinal trajectories of Alzheimer’s ATN biomarkers in elderly persons without dementia by Meng-Shan Tan; Alzheimer’s Disease Neuroimaging Initiative; Xi Ji; Jie-Qiong Li; Wei Xu; Hui-Fu Wang; Chen-Chen Tan; Qiang Dong; Chuan-Tao Zuo; Lan Tan; John Suckling; Jin-Tai Yu is a Medicine article available to read on EtoBox.
What is Longitudinal trajectories of Alzheimer’s ATN biomarkers in elderly persons without dementia about?
## Background Models of Alzheimer’s disease (AD) pathophysiology posit that amyloidosis [A] precedes and accelerates tau pathology [T] that leads to neurodegeneration [N]. Besides this A-T-N sequence, other biomarker sequences are possible. This current work investigates and compares the longitudinal trajectories of Alzheimer’s ATN biomarker profiles in non-demented elderly adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. ## Methods Based on the ATN classification system, 262 individuals were identified before dementia diagnosis and accompanied by baseline and follow-up data of ATN biomarkers (CSF Aβ42, p-tau, and FDG-PET). We recorded the conversion processes in ATN biomarkers during follow-up, then analyzed the possible longitudinal trajectories and estimated the conversion rate and temporal evolution of biomarker changes. To evaluate how biomarkers changed over time, we used linear mixed-effects models. ## Results During a 6–120-month follow-up period, there were four patterns of longitudinal changes in Alzheimer’s ATN biomarker profiles, from all negative to positive through the course of the disease. The most common pattern is that A pathology biomark
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- Author
- Meng-Shan Tan; Alzheimer’s Disease Neuroimaging Initiative; Xi Ji; Jie-Qiong Li; Wei Xu; Hui-Fu Wang; Chen-Chen Tan; Qiang Dong; Chuan-Tao Zuo; Lan Tan; John Suckling; Jin-Tai Yu
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); Springer Science and Business Media LLC (ISSN 1758-9193)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)