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Can I read True Chromogranin a concentrations in plasma from patients with small intestinal neuroendocrine tumours on EtoBox?
True Chromogranin a concentrations in plasma from patients with small intestinal neuroendocrine tumours by Rehfeld, Jens F.; Broedbaek, Kasper; Goetze, Jens P.; Knigge, Ulrich; Hilsted, Linda M. is a Medicine article available to read on EtoBox.
What is True Chromogranin a concentrations in plasma from patients with small intestinal neuroendocrine tumours about?
: The incidence of enteropancreatic neuroendocrine tumours (NET) is increasing. Chromogranin A (CgA) in plasma is a marker in patients suspected of NET tumours. CgA, however, is a precursor protein subjected to cellular processing that challenges quantitation and hence the use of CgA in diagnostics.: CgA concentrations in plasma sampled from 130 well-characterized patients with small intestinal NETs and from 30 healthy subjects were measured with eight commercial CgA kits, an in-house radioimmunoassay (RIA) and a processing-independent assay (PIA). For the evaluation of diagnostic accuracy, we performed regression analyses and plotted receiver-operating characteristic curves (ROC). The specificity was further assessed by size chromatography.: Five commercial assays (Thermo-Fisher, DRG Diagnostics, Eurodiagnostica (RIA and ELISA), and Phoenix), displayed a diagnostic accuracy with area under the curve (AUC) values >0.90, whereas three immunoassays (Yanaihara, CisBio RIA, and CisBio ELISA) discriminated poorly between disease stages (AUC: 0.60-0.78). Compared with the in-house assays, however, even the most accurate commercial immunoassay still missed patients with metastatic disease
Who reads True Chromogranin a concentrations in plasma from patients with small intestinal neuroendocrine tumours?
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- Author
- Rehfeld, Jens F.; Broedbaek, Kasper; Goetze, Jens P.; Knigge, Ulrich; Hilsted, Linda M.
- Publisher
- Informa plc; Informa UK (Taylor & Francis); Taylor & Francis; Informa UK Limited (ISSN 0036-5521)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)