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detected by using SE-iFISH technique in peripheral blood. 6.5ml peripheral blood was collected before chemotherapy combined with antiangiogenic therapy and after 2 cycles. The changes of CTCs and CTECs before and after treatment were compared, and the correlation between CTCs, CTECs and its clinical efficacy and survival was analyzed after 6 cycles of treatment. Results: In16 NSCLC patients, the number of CTCs was 0-20 /6.5ml whole blood (median 5), and the number of CTECs was 0-38 /6.5ml whole blood (median 4) before treatment. After 2 cycles, the number of CTCs was 1-89 /6.5ml whole blood (median 6), and the number of CTECs was 0-21 /6.5ml whole blood (median 4). Of the 16 patients, 7/16 (43.75%) patients' CTCs count decreased after 2 cycles of chemotherapy combined with anti-angiogenic therapy. Only 1 patient had RECIST1.1 system assessment of disease progression (PD), and its disease control rate (DCR) was 85.71% (6/7), which was higher than the DCR 66.67% (6/9) increased by CTCs count. The DCR of 9 patients with decreased CTECs count was 77.78% (7/9), and the median PFS time was 8.3m(7.1m-9.5m), while 3 patients with increased CTECs count developed PD, DCR was only 57.14 (4/7)
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- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)