Can I read Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response on EtoBox?
Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response by Brittany P. Rickard; Christina Conrad; Aaron J. Sorrin; Mustafa Kemal Ruhi; Jocelyn C. Reader; Stephanie A. Huang; Walfre Franco; Giuliano Scarcelli; William J. Polacheck; Dana M. Roque; Marcela G. del Carmen; Huang-Chiao Huang; Utkan Demirci; Imran Rizvi is a Medicine article available to read on EtoBox.
What is Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response about?
Ascites refers to the abnormal accumulation of fluid in the peritoneum resulting from an underlying pathology, such as metastatic cancer. Among all cancers, advanced-stage epithelial ovarian cancer is most frequently associated with the production of malignant ascites and is the leading cause of death from gynecologic malignancies. Despite decades of evidence showing that the accumulation of peritoneal fluid portends the poorest outcomes for cancer patients, the role of malignant ascites in promoting metastasis and therapy resistance remains poorly understood. This review summarizes the current understanding of malignant ascites, with a focus on ovarian cancer. The first section provides an overview of heterogeneity in ovarian cancer and the pathophysiology of malignant ascites. Next, analytical methods used to characterize the cellular and acellular components of malignant ascites, as well the role of these components in modulating cell biology, are discussed. The review then provides a perspective on the pressures and forces that tumors are subjected to in the presence of malignant ascites and the impact of physical stress on therapy resistance. Treatment options for malignant as
Who reads Malignant Ascites in Ovarian Cancer: Cellular, Acellular, and Biophysical Determinants of Molecular Characteristics and Therapy Response?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Brittany P. Rickard; Christina Conrad; Aaron J. Sorrin; Mustafa Kemal Ruhi; Jocelyn C. Reader; Stephanie A. Huang; Walfre Franco; Giuliano Scarcelli; William J. Polacheck; Dana M. Roque; Marcela G. del Carmen; Huang-Chiao Huang; Utkan Demirci; Imran Rizvi
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)