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The Gut-joint Axis in Spondyloarthritis: Immunological, Microbial, and Clinical Insights by Zoya Qaiyum; Melissa Lim; Robert D. Inman is a Immunology and Microbiology article available to read on EtoBox.

What is The Gut-joint Axis in Spondyloarthritis: Immunological, Microbial, and Clinical Insights about?

The strong genetic and clinical overlaps between spondyloarthritis (SpA) and inflammatory bowel disease (IBD) have placed much needed focus on the gut-joint axis of inflammation in SpA, leading to three key hypotheses that attempt to unravel this complex relationship. The arthritogenic peptide hypothesis and the aberrant cellular trafficking hypothesis have been put forth to rationalize the manner by which the innate and adaptive immune systems cooperate and converge during SpA pathogenesis. The bacterial dysbiosis hypothesis discusses how changes in the microbiome lead to architectural and immunological consequences in SpA. These theories are not mutually exclusive, but can provide an explanation as to why subclinical gut inflammation may sometimes precede joint inflammation in SpA patients, thereby implying a causal relationship. Such investigations will be important in informing therapeutic decisions which may be common to both SpA and IBD. However, these hypotheses can also offer insights for a coincident inflammatory relationship between the gut and the joint, particularly when assessing the immunological players involved. Insights from understanding how these systems might af

Who reads The Gut-joint Axis in Spondyloarthritis: Immunological, Microbial, and Clinical Insights?

Author

Zoya Qaiyum; Melissa Lim; Robert D. Inman

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)