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Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease by Randrita Pal; Supriyo Choudhury; Hrishikesh Kumar; Sanjit Dey; Nilansu Das; Barnali Ray Basu is a Neuroscience article available to read on EtoBox.

What is Vitamin D deficiency and genetic polymorphisms of vitamin D‐associated genes in Parkinson's disease about?

## Abstract Parkinson's disease (PD) and vitamin D share a unique link as vitamin D deficiency (VDD) prevails in PD. Thus, an in‐depth understanding of vitamin D biology in PD might be crucial for therapeutic strategies emphasising vitamin D. Specifically, explicating the effect of VDD and genetic polymorphisms of vitamin D‐associated genes in PD, like VDR (vitamin D receptor) or GC (vitamin D binding protein) may aid the process along with polymorphisms of vitamin D metabolising genes (e.g., CYP2R1 and CYP27A1) in PD. Literature review of single nucleotide polymorphisms (SNPs) related to vitamin D levels [GC (GC1‐rs7041 and GC2‐rs4588), CYP2R1, CYP24A1 and CYP27B1] and vitamin D function [VDR (FokI ‐ rs2228570 and rs10735810; ApaI ‐ rs7976091, rs7975232BsmI and rs1544410; and TaqI ‐ rs731236)] was conducted to explore their relationship with PD severity globally. VDR‐FokI polymorphism was reported to be significantly associated with PD in Hungarian, Chinese and Japanese populations, whereas VDR‐ApaI polymorphism was found to affect PD in the Iranian population. However, VDR‐TaqI and BsmI polymorphisms had no significant association with PD severity. Conversely, GC1 polymorphisms r

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Author

Randrita Pal; Supriyo Choudhury; Hrishikesh Kumar; Sanjit Dey; Nilansu Das; Barnali Ray Basu

Publisher

Wiley

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)