Can I read Remdesivir plus dexamethasone is associated to improvement in the clinical outcome of COVID-19 hospitalized patients regardless of their vaccination status on EtoBox?

Remdesivir plus dexamethasone is associated to improvement in the clinical outcome of COVID-19 hospitalized patients regardless of their vaccination status by Enrique Bernal; Eva García-Villalba; Eduardo Pons; Maria Dolores Hernández; Carlos Báguena; Gabriel Puche; Paula Carter; Mónica Martinez; Antonia Alcaraz; Cristina Tomás; Angeles Muñoz; Maria Rosario Vicente; Maria Luz Nuñez; Natalia Sancho; Mari Carmen Villalba; Alfredo Cano; Alfredo Minguela is a Medicine article available to read on EtoBox.

What is Remdesivir plus dexamethasone is associated to improvement in the clinical outcome of COVID-19 hospitalized patients regardless of their vaccination status about?

Introduction Remdesivir seems to reduce the risk of hospitalization and improve clinical outcome in hospitalized patients with COVID-19. Objectives To compare the clinical outcome of COVID-19 hospitalized patients treated with remdesivir plus dexamethasone versus dexamethasone alone, according to their vaccination status. Material and methods A retrospective observational study was carried out in 165 patients hospitalized for COVID-19 from October 2021 to January 2022. Multivariate logistic regression, Kaplan–Meier and the log-rank tests were used to evaluate the event (need for ventilation or death). Results Patients treated with remdesivir plus dexamethasone (n =87) compared with dexamethasone alone (n =78) showed similar age (60±16, 47–70 vs. 62±37, 51–74 years) and number of comorbidities: 1 (0–2) versus 1.5 (1–3). Among 73 fully vaccinated patients, 42 (47.1%) were in remdesivir plus dexamethasone and 31 (41%) in dexamethasone alone. Patients treated with remdesivir plus dexamethasone needed intensive care less frequently (17.2% vs. 31%; p =0.002), high-flow oxygen (25.3% vs. 50.0%; p =0.002) and non-invasive mechanical ventilation (16.1% vs. 47.4%; p <0.001). Furthermore, the

Who reads Remdesivir plus dexamethasone is associated to improvement in the clinical outcome of COVID-19 hospitalized patients regardless of their vaccination status?

Author

Enrique Bernal; Eva García-Villalba; Eduardo Pons; Maria Dolores Hernández; Carlos Báguena; Gabriel Puche; Paula Carter; Mónica Martinez; Antonia Alcaraz; Cristina Tomás; Angeles Muñoz; Maria Rosario Vicente; Maria Luz Nuñez; Natalia Sancho; Mari Carmen Villalba; Alfredo Cano; Alfredo Minguela

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)