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Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study by Maria Heinrich; Anika Müller; Andela Cvijan; Rudolf Mörgeli; Jochen Kruppa; Georg Winterer; Arjen J. C. Slooter; Claudia D. Spies; the BioCog Consortium is a Medicine article available to read on EtoBox.

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## Background Postoperative delirium (POD) is a frequent and serious complication after surgery. Evidence of a relationship between anticholinergic medication and the development of delirium is inconclusive, but studies on POD are rare. ## Objectives The objective of this study was to evaluate the anticholinergic load of preoperative medication in older adult patients and its association with the development of POD. ## Methods This investigation was part of the European BioCog project (http://www.biocog.eu), a prospective multicenter observational study in older adult surgical patients (ClinicalTrials.gov identifier: NCT02265263, 15 October 2014). Patients with a Mini–Mental State Examination score ≤ 23 points were excluded. POD was assessed up to 7 days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. The preoperative anticholinergic load was calculated using the Anticholinergic Drug Scale (ADS), the Anticholinergic Risk Scale (ARS) and the Anticholinergic Cognitive Burden Scale (ACBS), and associations with POD were analyzed using logistic regression analysis adjusting for age, comorbidities, duration of anesthesia

Who reads Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study?

Author

Maria Heinrich; Anika Müller; Andela Cvijan; Rudolf Mörgeli; Jochen Kruppa; Georg Winterer; Arjen J. C. Slooter; Claudia D. Spies; the BioCog Consortium

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)