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Management of primary anal canal adenocarcinoma: A large retrospective study from the Rare Cancer Network by Yazid Belkacémi; Christine Berger; Philip Poortmans; Gaëlle Piel; Abderrahim Zouhair; Jean-Baptiste Méric; Tan-Dat Nguyen; Marco Krengli; Franck Behrensmeier; Abdelkarim Allal; Dany De Looze; Jacques Bernier; Luciano Scandolaro; René-Olivier Mirimanoff is a Medicine article available to read on EtoBox.

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## Purpose: Primary adenocarcinoma of the anus is a rare tumor. the current standard treatment consists of abdominoperineal resection (apr). the aim of this rare cancer network study was to evaluate the prognostic factors and outcome after the three most commonly used treatment approaches. ## Methods and materials: This multicenter study collected data from 82 patients: 15 with t1 (18%), 34 with t2 (42%), 22 with t3 (27%), and 11 with t4 (13%) tumors according to the tnm classification (international union against cancer, 1997). patients were separated into, and analyzed according to, three treatment categories: radiotherapy/surgery (rt/s group, n = 45), combined radiochemotherapy (rt/cht group, n = 31), and apr alone (apr group, n = 6). the main patient characteristics were evenly distributed among the three groups. ## Results: The actuarial locoregional relapse rate at 5 years was 37%, 36%, and 20%, respectively, in the rt/s, rt/cht, and apr groups (rt/s vs. rt/cht, p = 0.93; rt/ch vs. apr, p = 0.78). the 3-, 5-, and 10-year overall survival rate was 47%, 29%, and 23% in the rt/s group, 75%, 58%, and 39% in the rt/cht group, and 42%, 21%, and 21% in the apr group (rt/cht vs. rt/s

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Author

Yazid Belkacémi; Christine Berger; Philip Poortmans; Gaëlle Piel; Abderrahim Zouhair; Jean-Baptiste Méric; Tan-Dat Nguyen; Marco Krengli; Franck Behrensmeier; Abdelkarim Allal; Dany De Looze; Jacques Bernier; Luciano Scandolaro; René-Olivier Mirimanoff

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2003

Language

EN

Field

Medicine (Health Sciences)