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Oxidative Stress Mediates the Associations Between Phthalate Exposures and Thyroid Cancer/benign Nodule Risk by Chong Liu; Long-Qiang Wang; Min Zhang; Yan-Ling Deng; Qiong Luo; Er-Nan Liu; Pan-Pan Chen; Yu Miao; Pan Yang; Qiang Zeng is a Environmental Science article available to read on EtoBox.
What is Oxidative Stress Mediates the Associations Between Phthalate Exposures and Thyroid Cancer/benign Nodule Risk about?
Epidemiological studies have suggested that phthalate exposures are associated with increased risks of thyroid cancer and benign nodule, while the underlying mechanisms are largely unknown. Here, we explored the mediation effects of oxidative stress (OS) biomarkers in the associations between phthalate exposures and the risks of thyroid cancer and benign nodule. Urine samples collected from 143 thyroid cancer, 136 nodule patients, and 141 healthy controls were analyzed for 8 phthalate metabolites and 3 OS biomarkers [8-hydroxy-2-deoxyguanosine (8-OHdG), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), and 8-iso-prostaglandin F2α (8-isoPGF2α)]. Multivariable linear or logistic regression models were used to explore the associations of OS biomarkers with phthalate metabolite concentrations and the risks of thyroid cancer and nodule. The mediation role of OS biomarkers was also investigated. Urinary monoethyl phthalate (MEP), monomethyl phthalate (MMP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP), mono (2-ethylhexyl) phthalate (MEHP), and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) were positively associated with at least 2 OS biomarkers (all P-values<0.01), and part of these positi
Who reads Oxidative Stress Mediates the Associations Between Phthalate Exposures and Thyroid Cancer/benign Nodule Risk?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Chong Liu; Long-Qiang Wang; Min Zhang; Yan-Ling Deng; Qiong Luo; Er-Nan Liu; Pan-Pan Chen; Yu Miao; Pan Yang; Qiang Zeng
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)