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An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts by Jeffrey R. Ryan; Jay F. Levine; Charles S. Apperson; Lori Lubke; Robert A. Wirtz; Patricia A. Spears; Paul E. Orndorff is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts about?
The prokaryotic, spirochaetal microorganism __Borrelia burgdorferi__ is the causative agent of Lyme disease, an arthropod‐borne disease of a variety of vertebrates and the most prevalent arthropod‐borne disease of humans in the United States. In order to understand better the normal life cycle of __B. burgdorferi__, an experimental chain of infection was devised that involved multiple sequential arthropod and mammalian passages. By examining populations of __B. burgdorferi__ emerging from different points in this infectious chain, we demonstrate that selection of __B. burgdorferi__ populations peculiar to arthropod or vertebrate hosts is a property of at least one of the two ecologically distinct strains we examined. Distinct __B. burgdorferi__ populations were identified using an antigenic profile, defined by a set of monoclonal antibodies to eight __B. burgdorferi__ antigens, and a plasmid profile, defined by the naturally occurring plasmids in the starting clonal populations. These two profiles constituted the phenotypical signature of the population. In the strain exhibiting selection in the different hosts, transition from one host to another produced a striking series of alte
Who reads An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jeffrey R. Ryan; Jay F. Levine; Charles S. Apperson; Lori Lubke; Robert A. Wirtz; Patricia A. Spears; Paul E. Orndorff
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)