Can I read Stronger Gut Microbiome Modulatory Effects by Postbiotics Than Probiotics in a Mouse Colitis Model on EtoBox?

Stronger Gut Microbiome Modulatory Effects by Postbiotics Than Probiotics in a Mouse Colitis Model by Tao Zhang; Weiqin Zhang; Cuijiao Feng; Lai-Yu Kwok; Qiuwen He; Zhihong Sun is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Stronger Gut Microbiome Modulatory Effects by Postbiotics Than Probiotics in a Mouse Colitis Model about?

## Abstract Probiotics are increasingly used as adjunctive therapy to manage gastrointestinal diseases, such as ulcerative colitis. However, probiotic use has posed some safety concerns. Thus, postbiotics are proposed as alternatives to probiotics in clinical applications. However, no study has directly compared the clinical benefits of probiotics and postbiotics. This study compared the beneficial effect of postbiotics and probiotics derived from the strain, Bifidobacterium adolescentis B8589, in a dextran sulfate sodium (DSS)-induced experimental colitis mouse model. Four groups of mice (n = 7 per group) were included in this work: Control (received water plus saline), DSS (received DSS without postbiotic/probiotic), Postbiotic (received DSS plus postbiotic), and Probiotic (received DSS plus probiotic). Our results showed that intragastric administration of both probiotic and postbiotic ameliorated colitis, reflected by decreased histology scores in Postbiotic and Probiotic groups compared with DSS group (P < 0.05). The fecal microbiota alpha diversity was not significantly affected by DSS-, postbiotic, or probiotic treatment. However, the postbiotic treatment showed stronger eff

Who reads Stronger Gut Microbiome Modulatory Effects by Postbiotics Than Probiotics in a Mouse Colitis Model?

Author

Tao Zhang; Weiqin Zhang; Cuijiao Feng; Lai-Yu Kwok; Qiuwen He; Zhihong Sun

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)