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Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial by Maryam Karamali; Zahra Heidarzadeh; Seyed Morteza Seifati; Mansooreh Samimi; Zohreh Tabassi; Mohammad Hajijafari; Zatollah Asemi; Ahmad Esmaillzadeh is a Medicine article available to read on EtoBox.
What is Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial about?
## Objective: To the best of our knowledge, no reports are available indicating the effects of zinc supplementation on metabolic status in women with gestational diabetes (gdm). this study was designed to determine the effects of zinc supplementation on glucose homeostasis parameters and lipid concentrations in gdm women. ## Methods: This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with gdm, primigravida and aged 18-40years old. patients were randomly divided into two groups to receive 233mg zinc gluconate (containing 30mg zinc) supplements (n=29) or placebo (n=29) per day for 6weeks. fasting blood samples were taken at the beginning and end of the trial to quantify glucose, insulin and lipid concentrations. ## Results: Patients who received zinc supplements had significantly higher serum zinc concentrations (+6.9±13.2 vs. -1.5±16.5mg/dl, p=0.03) than those received the placebo. in addition, zinc-supplemented patients had reduced fasting plasma glucose (fpg) (-6.6±11.2 vs. +0.6±6.7mg/dl, p=0.005), serum insulin levels (-1.3±6.6 vs. +6.6±12.2μiu/ml, p=0.003), homeostasis model of assessment-insulin resistance (homa-ir) (-0.5±1.6 vs. +1.5
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- Author
- Maryam Karamali; Zahra Heidarzadeh; Seyed Morteza Seifati; Mansooreh Samimi; Zohreh Tabassi; Mohammad Hajijafari; Zatollah Asemi; Ahmad Esmaillzadeh
- Publisher
- Elsevier BV
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)