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Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model by Julio Echegoyen; Caren Armstrong; Robert J. Morgan; Ivan Soltesz is a Medicine article available to read on EtoBox.

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Effective prophylaxis for post-traumatic epilepsy currently does not exist, and clinical trials using anticonvulsant drugs have yielded no long-term antiepileptogenic effects. We report that a single, rapid post-traumatic application of the proconvulsant cannabinoid type-1 (CB1) receptor antagonist SR141716A (Rimonabant-Acomplia ® ) abolishes the long-term increase in seizure susceptibility caused by head injury in rats. These results indicate that, paradoxically, a seizure-enhancing drug may disrupt the epileptogenic process if applied within a short therapeutic time window.

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Author

Julio Echegoyen; Caren Armstrong; Robert J. Morgan; Ivan Soltesz

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2009

Language

EN

Field

Medicine (Health Sciences)