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Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC) by Clarisse S Muenyi; Vanessa A States; Joshua H Masters; Teresa W Fan; C William Helm; J Christopher States is a Medicine article available to read on EtoBox.

What is Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC) about?

## Abstract ## Background Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death in the USA. Recurrence rates are high after front-line therapy and most patients eventually die from platinum (Pt) - resistant disease. Cisplatin resistance is associated with increased nucleotide excision repair (NER), decreased mismatch repair (MMR) and decreased platinum uptake. The objective of this study is to investigate how a novel combination of sodium arsenite (NaAsO~2~) and hyperthermia (43°C) affect mechanisms of cisplatin resistance in ovarian cancer. ## Methods We established a murine model of metastatic EOC by intraperitoneal injection of A2780/CP70 human ovarian cancer cells into nude mice. We developed a murine hyperthermic intraperitoneal chemotherapy model to treat the mice. Mice with peritoneal metastasis were perfused for 1 h with 3 mg/kg cisplatin ± 26 mg/kg NaAsO~2~ at 37 or 43°C. Tumors and tissues were collected at 0 and 24 h after treatment. ## Results Western blot analysis of p53 and key NER proteins (ERCC1, XPC and XPA) and MMR protein (MSH2) suggested that cisplatin induced p53, XPC and XPA and suppressed MSH2 consistent with resistant phenotype. Hy

Who reads Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)?

Author

Clarisse S Muenyi; Vanessa A States; Joshua H Masters; Teresa W Fan; C William Helm; J Christopher States

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, c2008-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1757-2215)

Published

2011

Language

EN

Field

Medicine (Health Sciences)