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Long‐term in vivo stability of rabbit nasal septal cartilage following laser cartilage reshaping: A pilot investigation by Amir M. Karamzadeh; John C. Chang; Sergio Diaz; Thomas E. Milner; Brian J.F. Wong is a Medicine article available to read on EtoBox.
What is Long‐term in vivo stability of rabbit nasal septal cartilage following laser cartilage reshaping: A pilot investigation about?
## Abstract ## Background and Objectives To evaluate the long‐term effect of laser cartilage reshaping on rabbit nasal septal cartilage viability and mechanical integrity in an in vivo model. ## Study Design/Materials and Methods In vivo animal investigation. Rabbit septal cartilage specimens were laser (Nd:YAG, λ = 1.32 μm, spot size 5.4‐mm diameter, 10 W, 10 seconds, 50 Hz PPR) reshaped and subsequently reimplanted into an interscapular subcutaneous pocket. Specimens were harvested at 8 and 12 months and evaluated using photography, flow cytometry, and histology. ## Results Grossly, specimens showed alteration in the physical integrity with varying degrees of tissue resorption. The non‐irradiated control specimens demonstrated significantly increased stiffness. Histologically, there was marked depletion of the extracellular matrix and an overall reduction in tissue mass in laser irradiated tissues. However, flow cytometry data identified viable chondrocytes in laser‐irradiated specimens that were identical to those observed in controls. ## Conclusions Study results demonstrate that the rabbit nasal septal cartilage model can be effectively used to study laser reshaping, however a
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- Author
- Amir M. Karamzadeh; John C. Chang; Sergio Diaz; Thomas E. Milner; Brian J.F. Wong
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)