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Can I read Gemcitabine/nab‐paclitaxel vs Gemcitabine/carboplatin for Advanced Urothelial Carcinoma on EtoBox?
Gemcitabine/nab‐paclitaxel vs Gemcitabine/carboplatin for Advanced Urothelial Carcinoma by Xin An; Cong Xue; Meiting Chen; Mengqian Ni; Huali Ma; Li Tian; Riqing Huang; Xiangdong Li; Yunlin Ye; Tao Qin; Pei Dong; Zhiyong Li; Jing Peng; Kai Yao; Fangjian Zhou; Zhuowei Liu; Yanxia Shi is a Medicine article available to read on EtoBox.
What is Gemcitabine/nab‐paclitaxel vs Gemcitabine/carboplatin for Advanced Urothelial Carcinoma about?
## Background Nanoparticle albumin‐bound (nab)‐paclitaxel shows promising activity and tolerability in platinum‐refractory metastatic urothelial cancer (mUC).This phase III trial aimed to compare the efficacy and safety of nab‐paclitaxel plus gemcitabine (GA) with that of carboplatin plus gemcitabine (GCb) as a first‐line treatment for patients with cisplatin‐ineligible mUC. ## Patients and method Treatment‐naive, cisplatin‐ineligible patients with mUC were assigned randomly to either the GA (both nab‐paclitaxel 125 mg/m^2^ and gemcitabine 1,000 mg/m^2^ on days 1 and 8, every 21 days) or GCb group (carboplatin AUC 4.5 on day 1, gemcitabine 1000 mg/m^2^ on days 1 and 8, every 21 days). The primary endpoint was progression‐free survival (PFS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), overall survival (OS), safety and patient‐reported outcomes (PROs). ## Results The trial was terminated early because of slow accrual after 54 patients were enrolled: 26 in in the GA group and 28 in the GCb groups. The median PFS was 6.7 months versus 5.9 months for the GA and GCb groups, respectively (__P__=0.248). The median OS time was 12.1 versus 10.7 mo
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- Author
- Xin An; Cong Xue; Meiting Chen; Mengqian Ni; Huali Ma; Li Tian; Riqing Huang; Xiangdong Li; Yunlin Ye; Tao Qin; Pei Dong; Zhiyong Li; Jing Peng; Kai Yao; Fangjian Zhou; Zhuowei Liu; Yanxia Shi
- Publisher
- Wiley
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)