About this Medicine article

Male Gonadal Function After Chemotherapy in Survivors of Childhood Malignancy by Carmen Mustieles; Arturo Muñoz; Milagros Alonso; Purificación Ros; Rafael Yturriaga; Soledad Maldonado; Enrique Otheo; Raquel Barrio is a Medicine article available to read on EtoBox.

## Abstract Investigations of adult patients have shown that chemotherapy causes gonadal damage, but much less information is available about the impact of chemotherapy on gonadal function in children with malignant disease. At one time, being prepubertal during therapy was thought to confer some protection against chemotherapy induced gonadal damage. However, recent studies have indicated otherwise. We designed this study to assess gonadal function in 15 postpubertal males who had received polychemotherapy for a malignant disease during childhood and we compared them with 13 control adults males. The mean age of the patients at the time of the study was 18.2 ± 3.6 years (range 13.8–29.0), and when given chemotherapy treatment was 10.2 ± 3.0 years (range 6–16). At that time 12 were prepubertal and at the time of the study all were Tanner V. The mean interval from the completion of treatment until the study was 6.42 years (range 2.0–16.5). All patients had received polychemotherapy. We evaluated testicular size, sperm counts, LH and FSH after GnRH test, and testosterone levels. Puberty had progressed normally in all patients. We found no significant differences in testosterone and b

Author

Carmen Mustieles; Arturo Muñoz; Milagros Alonso; Purificación Ros; Rafael Yturriaga; Soledad Maldonado; Enrique Otheo; Raquel Barrio

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1995

Language

EN

Field

Medicine (Health Sciences)