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Adult Respiratory Distress Syndrome in Severely Neutropenic Children by Yakov Sivan; Celia Mor; Sana Al-Jundi; Dr. Christopher J. L. Newth is a Medicine article available to read on EtoBox.

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## Abstract It has been suggested that polymorphonuclear cells (PMNs) are required for the development of the adult respiratory distress syndrome (ARDS). We investigated the occurrence of ARDS with acute respiratory failure in 30 children with severe neutropenia (<500 PMNs/mm^3^) who met the clinical diagnostic criteria for ARDS and in whom postmortem histopathology findings were available within 7 days of the onset of ARDS. In 26 patients the histopathology was consistent with ARDS. In 12/26 children no white blood cells (WBC) were found in the lung tissue, 10/26 had moderate infiltration of mononuclear cells, 2/26 had massive tumor cell infiltration, and in 2/26 PMNs were found. Thus, in at least 22/26 patients ARDS developed without neutrophilic infiltration of the lungs. The maximum active lung infection rate was found to be 69% (18/26) by endotracheal and post mortem lung cultures and histology. Thus 5/26 children had ARDS without any WBC in the lung tissue. We conclude, as have other studies in adults that the absence of PMNs does not protect children from the development of ARDS and that the mechanism which involves PMNs is probably only one of several pathways for diffuse a

Who reads Adult Respiratory Distress Syndrome in Severely Neutropenic Children?

Author

Yakov Sivan; Celia Mor; Sana Al-Jundi; Dr. Christopher J. L. Newth

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

1990

Language

EN

Field

Medicine (Health Sciences)