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What is Transgenic Animals in Target Validation about?

Transgenic animals are genetically modified organisms used in target validation for drug discovery, with common models including knockout, overexpression, humanized, and reporter gene models. They offer advantages such as mimicking human disease mechanisms and enabling in vivo validation, but also face limitations like high costs and ethical concerns. The use of these models is evolving with advancements in technologies like CRISPR.

Author

nehanjalislp

Language

EN