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Can I read Innovation by Homologous Recombination on EtoBox?
Innovation by Homologous Recombination by Devin L Trudeau; Matthew A Smith; Frances H Arnold is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Innovation by Homologous Recombination about?
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries. Recombination has generated proteins with diverse thermostability and mechanical stability, enzyme substrate specificity, and optogenetic properties. Linear regression, Gaussian processes, and support vector machine learning have been used to model sequence-function relationships and predict useful chimeras. These approaches enable engineering of protein chimeras with desired functions, as well as elucidation of the structural basis for these functions.
Who reads Innovation by Homologous Recombination?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Devin L Trudeau; Matthew A Smith; Frances H Arnold
- Publisher
- Elsevier BV
- Published
- 2013
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)