Can I read The Role of Ion Channels in Insulin Secretion on EtoBox?

The Role of Ion Channels in Insulin Secretion by A. E. Boyd III is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The Role of Ion Channels in Insulin Secretion about?

## Abstract Ion channels in beta cells regulate electrical and secretory activity in response to metabolic, pharmacologic, or neural signals by controlling the permeability to K^+^ and Ca^2+^. The ATP‐sensitive K^+^ channels act as a switch that responds to fuel secretagogues or sulfonylureas to initiate depolarization. This depolarization opens voltage‐dependent calcium channels (VDCC) to increase the amplitude of free cytosolic Ca^2+^ levels ([Ca^2+^]i), which triggers exocytosis. Acetyl choline and vasopressin (VP) both potentiate the acute effects of glucose on insulin secretion by generating inositol 1,4,5‐trisphosphate to release intracellular Ca^2+^; VP also potentiates sustained insulin secretion by effects on depolarization. In contrast, inhibitors of insulin secretion decrease [Ca^2+^]i by either hyperpolarizing the beta cell or by receptor‐mediated, G‐protein‐coupled effects to decrease VDCC activity. Repolarization is initiated by voltage‐ and Ca^2+^‐activated K^+^ channels. A human insulinoma voltage‐dependent K^+^ channel cDNA was recently cloned and two types of alpha1 subunits of the VDCC have been identified in insulin‐secreting cell lines. Determining how ion chan

Who reads The Role of Ion Channels in Insulin Secretion?

Author

A. E. Boyd III

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)