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CCR1 is an early and specific marker of Alzheimer's disease by Meredith Halks‐Miller; Miriam L. Schroeder; Vahram Haroutunian; Ursula Moenning; Michael Rossi; Cristian Achim; Dushyant Purohit; Mithra Mahmoudi; Richard Horuk is a Medicine article available to read on EtoBox.

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## Abstract Chemokines are a diverse group of small proteins that effect cell signaling by binding to G‐protein–coupled, seven‐trans‐membrane receptors. Our group had found previously that the chemokine receptor CCR1 was present in neurons and dystrophic processes in a small sample of Alzheimer's disease cases. This expanded immunohistochemical study shows that the number of CCR1‐positive plaque‐like structures in the hippocampus and entorhinal cortex is highly correlated to dementia state as measured by the clinical dementia rating score. CCR1 immunoreactivity is found in dystrophic, neurofilament‐positive, synaptophysin‐negative neurites that are associated with senile plaques containing amyloid beta peptides of the 1‐42 species (Aβ42). CCR1 was not, however, associated with diffuse deposits of Aβ42. There was limited expression of CCR1 in neurofibrillary tangle‐bearing neuritic processes. Astrocytes and microglia were typically negative for CCR1. Human brains from age‐matched, nondemented individuals rarely displayed either CCR1 or Aβ42 immunoreactivity. Seven other types of dementing neurodegenerative diseases were examined, and all failed to demonstrate CCR1 immunopositivity u

Who reads CCR1 is an early and specific marker of Alzheimer's disease?

Author

Meredith Halks‐Miller; Miriam L. Schroeder; Vahram Haroutunian; Ursula Moenning; Michael Rossi; Cristian Achim; Dushyant Purohit; Mithra Mahmoudi; Richard Horuk

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0364-5134)

Published

2003

Language

EN

Field

Medicine (Health Sciences)