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Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy by Bjorn Redfors; Yangzhen Shao; Johannes Wikström; Alexander R. Lyon; Anders Oldfors; Li-Ming Gan; Elmir Omerovic is a Medicine article available to read on EtoBox.
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## Aims: Stress-induced cardiomyopathy (sic) is an important differential diagnosis to acute myocardial infarction (ami) that is associated with significant morbidity and mortality. the typical hallmark of sic is left-ventricular apical akinesia but preserved function in basal segments. catecholamines are postulated to play an important role in sic but the precise pathophysiology is incompletely understood. whether myocardial perfusion of the affected segments is impaired in sic has been debated and remains unknown. ## Methods and results: Myocardial contrast echocardiography (mce) was used to study regional myocardial perfusion in a rat model of sic. twelve rats received 50 mg/kg isoproterenol (iso) i.p. and were continuously monitored by mce. apical and basal perfusion were estimated and expressed as a ratio at baseline, 5, 10, 20, 30, 40, 50, 60, 70, 80, and 90 min post-iso. the rats developed typical apical ballooning after 43 ± 9 min post-iso injection. the ratio of apical:basal perfusion was close to 1.00 at all time-points and never dropped below 0.89 (95% ci never extended below 0.73). light and electron microcoscopical investigation revealed no structural damage of myocard
Who reads Contrast echocardiography reveals apparently normal coronary perfusion in a rat model of stress-induced (Takotsubo) cardiomyopathy?
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- Author
- Bjorn Redfors; Yangzhen Shao; Johannes Wikström; Alexander R. Lyon; Anders Oldfors; Li-Ming Gan; Elmir Omerovic
- Publisher
- Oxford University Press (OUP)
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)