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This study reports the synthesis and antibacterial evaluation of 22 novel pyrimidine derivatives, with compound 7c demonstrating the highest potency against various drug-resistant bacteria and fungi, including an MIC of 2.4 μmol/L. Molecular docking studies indicated that compound 7c interacts effectively with dihydrofolate reductase, suggesting its potential as a therapeutic agent. Additionally, toxicity assessments in human liver cells showed varying levels of safety among the compounds, highlighting the

Author

rakeshmallik2002

Language

EN