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Expression of T Lymphocyte Adhesion Molecules: Regulation During Antigen-Induced T Cell Activation and Differentiation by Dailey, Morris O. is a Immunology and Microbiology article available to read on EtoBox.

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The pattern of lymphocyte traffic and migration in vivo is a composite of constitutive recirculation and transient changes induced by interaction with antigen. Naive T lymphocytes in their basal, unstimulated state continuously recirculate throughout the entire host, poised to react to specific antigens that they are programmed to recognize. After interaction with antigen, T cell traffic changes, first with the trapping of reactive cells in antigen-containing lymphoid tissue. Subsequently, the effector cells responding to antigen, accompanied by nonspecific T cells and monocytes, traffic in large numbers to sites of antigen localization, resulting in the localized inflammatory response. Then, as the immune response wanes, memory T cells develop, many of which exhibit still different routes of recirculation. The traffic and tissue localization of leukocytes is regulated by a series of cell surface adhesion molecules that recognize specific ligands on endothelial cells and in the extracellular matrix. Modulation of the expression of these adhesion molecules results in the changes in T cell traffic that are characteristic of each stage of T cell differentiation. Thus, during T cell ac

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Author

Dailey, Morris O.

Publisher

Begell House Inc.; Begell House (ISSN 2162-6472)

Published

1998

Language

EN

Field

Immunology and Microbiology (Life Sciences)