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Resveratrol: Evidence for Its Nephroprotective Effect in Diabetic Nephropathy by Vemana Gowd; Qingzheng Kang; Qi Wang; Qiang Wang; Feng Chen; Ka-Wing Cheng is a Medicine article available to read on EtoBox.

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ABSTRACT Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Dietary habits play a major role in determining the onset and progression of DM-related disorders and a proper diet (rich in fruits and vegetables) can delay or prevent the process of DM pathogenesis. Thus, increasing attention has been paid to polyphenols and polyphenol-rich foods since their increased intake has been associated with a reduced incidence of DM and its associated complications. Resveratrol is a polyphenolic phytoalexin that is mainly found in grapevines and berries. It is available in various pharmaceutical dosages and is widely recommended as a dietary supplement due to its beneficial effects. Remarkably, resveratrol's capability to effectively lower blood glucose levels without any side effects has been amply demonstrated in many in vitro and in vivo studies. Herein, we comprehensively review and discuss the nephroprotective effect of resveratrol during DN and its associated mechanisms. Resveratrol exerts its nephroprotective effects via various mechanisms including reducing oxidative stress and advanced glycation end-product (AGE) production, stimulating autophagy, inhibiting e

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Author

Vemana Gowd; Qingzheng Kang; Qi Wang; Qiang Wang; Feng Chen; Ka-Wing Cheng

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)