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Prognostic role of serum prostatic acid phosphatase for 103Pd-based radiation for prostatic carcinoma by Michael Dattoli; Kent Wallner; Lawrence True; Richard Sorace; John Koval; Jennifer Cash; Rudolph Acosta; Mohendra Biswas; Michael Binder; Brent Sullivan; Emilio Lastarria; Novelle Kirwan; Douglas Stein is a Medicine article available to read on EtoBox.

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Purpose: To establish the prognostic role of serum enzymatic prostatic acid phosphatase (PAP) in patients treated with palladium ( 103 Pd) and supplemental external beam irradiation (EBRT) for clinically localized, high-risk prostate carcinoma. Methods and Materials: One hundred twenty-four consecutive patients with Stage T2a-T3 prostatic carcinoma were treated from 1992 through 1995. Each patient had at least one of the following risk factors for extracapsular disease extension: Stage T2b or greater (100 patients), Gleason score 7-10 (40 patients), pretreatment prostate specific antigen (PSA) > 15 ng/ml (32 patients), or elevated serum PAP (25 patients). Patients received 41 Gy conformal EBRT to a limited pelvic field, followed 4 weeks later by a 103 Pd boost (prescription dose 80 Gy). Biochemical failure was defined as a PSA greater than 1 ng/ml (normal < 4 ng/ml). Results: The overall, actuarial freedom from biochemical failure at 4 years after treatment was 79%. In Cox-proportional hazard multivariate analysis, the strongest predictor of failure was elevated pretreatment acid phosphatase (p ‫؍‬ 0.02), followed by Gleason score (p ‫؍‬ 0.1), and PSA (p ‫؍‬ 0.14). Conclusion: PAP

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Author

Michael Dattoli; Kent Wallner; Lawrence True; Richard Sorace; John Koval; Jennifer Cash; Rudolph Acosta; Mohendra Biswas; Michael Binder; Brent Sullivan; Emilio Lastarria; Novelle Kirwan; Douglas Stein

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1999

Language

EN

Field

Medicine (Health Sciences)