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Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication by Jia Zhao; Guang Xu; Xiaorong Hou; Wenqing Mu; Huijie Yang; Wei Shi; Jincai Wen; Tingting Liu; Zhixin Wu; Jun Bai; Ping Zhang; Zhongxia Wang; Xiaohe Xiao; Wenjun Zou; Zhaofang Bai; Xiaoyan Zhan is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication about?
Ethnopharmacological relevance Schisandra Chinensis (Turcz.) Baill. is a long-term used traditional Chinese medicine with the functions of tonifying the kidney and calming the heart, tonifying qi and engendering fluid. It can be used to treat insomnia and dreaminess, spermatorrhea, coughs, as well as liver and kidney deficiency of Yin or Yang Syndrome. Modern pharmacological studies have shown that Schisandra Chinensis regulates host immunity and exhibits anti-cancer, antiviral and liver-protecting effects. However, the specific mechanism by which Schisandra Chinensis modulates antiviral immunity is unknown. Aim of the study We sought to explore the therapeutic effect of the active components of Schisandra Chinensis on anti-viral immunity and further investigate the underlying mechanism. Materials and methods Immunoblotting, quantitative real-time PCR, enzyme-linked immunosorbent assay, immunofluorescence, and immunoprecipitation were used to investigate the effect of schisandrin C (SC), one of the most abundant and biologically active components of Schisandra Chinensis, on the activation of cGAS-STING signaling pathway and the underlying mechanism. In addition, CMA-mediated STING
Who reads Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Jia Zhao; Guang Xu; Xiaorong Hou; Wenqing Mu; Huijie Yang; Wei Shi; Jincai Wen; Tingting Liu; Zhixin Wu; Jun Bai; Ping Zhang; Zhongxia Wang; Xiaohe Xiao; Wenjun Zou; Zhaofang Bai; Xiaoyan Zhan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)