Opening book details…
Can I read Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease on EtoBox?
Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease by Hanna Engler; Dieter Koeberle; Beat Thuerlimann; Hans-Jörg Senn; Walter F. Riesen is a Medicine article available to read on EtoBox.
What is Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease about?
## Abstract Seventy cancer patients with malignant osteolytic bone disease received pamidronate every three weeks for a maximum of six cycles. Bone resorption parameters, urinary calcium excretion, and pain parameters were assessed at baseline and throughout the study. At baseline, 80–95 % of patients showed elevated urinary pyridinoline, deoxypyridinoline, Osteomark® NTx and serum ICTP® levels, whereas only 35 % of patients had elevated urinary CrossLaps® excretion rates. During bisphosphonate therapy, significant decreases in Osteomark® NTx, CrossLaps® and calcium excretion were observed, which were not related to the clinical outcome. The baseline levels of bone resorption markers were used to predict the probability of non-progressive bone disease or reduction in pain intensity during bisphosphonate therapy. Significant predictors of non-progressive bone disease were urinary pyridinoline and serum ICTP levels; significant predictors of reduction in pain intensity were urinary free deoxypyridinoline and serum ICTP levels. Our data indicate that serum ICTP levels predict significantly the response to bisphosphonate therapy in patients with advanced malignant osteolytic bone disea
Who reads Diagnostic and Prognostic Value of Biochemical Markers in Malignant Bone Disease: A Prospective Study on the Effect of Bisphosphonate on Pain Intensity and Progression of Malignant Bone Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hanna Engler; Dieter Koeberle; Beat Thuerlimann; Hans-Jörg Senn; Walter F. Riesen
- Publisher
- Walter de Gruyter GmbH
- Published
- 1998
- Language
- EN
- Field
- Medicine (Health Sciences)