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Novel Biodegradable Polymers as Gene Carriers by Yuan Yang; Wenxiang Jia; Xin Qi; Chun Yang; Li Liu; Zairong Zhang; Juhui Ma; Shaobing Zhou; Xiaohong Li is a Materials Science article available to read on EtoBox.
What is Novel Biodegradable Polymers as Gene Carriers about?
## Abstract **Summary:** This study investigated two new biodegradable polymers as gene controlled‐released coatings for gene transfer. Poly(ethylene glycol)‐__co__‐poly(D,L‐lactic acid) (PELA) and poly(ethylene glycol)‐__co__‐poly(lactic acid)‐__co__‐poly(glycolic acid) random copolymer (PELGA) were synthesized and used as microspheres matrices with encapsulated plasmid pCH110. The plasmid loading efficiency, cytotoxicity, transfection efficiency and in vitro degradation and release profiles of microsphere complexes were evaluated in details. The biodegradable polymers showed high DNA loading efficiency and low cytotoxicity as gene controlled‐released coatings, and the poly(ethylene glycol) (PEG) contents of polymer matrices influenced the diameter, loading efficiency and transfection efficiency of plasmid DNA within the microspheres. The average diameters of PELA and PELGA microspheres were between 0.5 and 1.5 μm, and the plasmid loading efficiency was 62 and 73% for PELA and PELGA microspheres with 10% PEG content, respectively. In vitro testing showed a gradual release profile of DNA from polymeric matrices. The polymers/DNA microspheres had high transfection efficiency and ear
Who reads Novel Biodegradable Polymers as Gene Carriers?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Yuan Yang; Wenxiang Jia; Xin Qi; Chun Yang; Li Liu; Zairong Zhang; Juhui Ma; Shaobing Zhou; Xiaohong Li
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)
- Published
- 2004
- Language
- EN
- Field
- Materials Science (Physical Sciences)