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Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis by Manon Giraudier; Carlos Ventura-Bort; Andreas M. Burger; Nathalie Claes; Martina D'Agostini; Rico Fischer; Mathijs Franssen; Michael Kaess; Julian Koenig; Roman Liepelt; Sander Nieuwenhuis; Aldo Sommer; Taras Usichenko; Ilse Van Diest; Andreas von Leupoldt; Christopher M. Warren; Mathias Weymar is a Neuroscience article available to read on EtoBox.

What is Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis about?

Background Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet. Methods The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release. Results While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity. Conclusion(s) Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers

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Author

Manon Giraudier; Carlos Ventura-Bort; Andreas M. Burger; Nathalie Claes; Martina D'Agostini; Rico Fischer; Mathijs Franssen; Michael Kaess; Julian Koenig; Roman Liepelt; Sander Nieuwenhuis; Aldo Sommer; Taras Usichenko; Ilse Van Diest; Andreas von Leupoldt; Christopher M. Warren; Mathias Weymar

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Neuroscience (Life Sciences)