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Can I read Design, Synthesis, and Biological Evaluation of Novel Stachydrine Derivatives as Potent Neuroprotective Agents for Cerebral Ischemic Stroke on EtoBox?
Design, Synthesis, and Biological Evaluation of Novel Stachydrine Derivatives as Potent Neuroprotective Agents for Cerebral Ischemic Stroke by Liang Zhang; Feng Li; Chenhui Hou; Sifeng Zhu; Lili Zhong; Jianchun Zhao; Cai Song; Wenbao Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Design, Synthesis, and Biological Evaluation of Novel Stachydrine Derivatives as Potent Neuroprotective Agents for Cerebral Ischemic Stroke about?
Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. When compared with stachydrine, Compound B1 exhibited better neuroprotective effects in vitro, and significantly reduced infarction size in the model of the middle cerebral artery occlusion rat model. Therefore, Compound B1 was selected for further research on ischemic stroke. Graphical abstract.
Who reads Design, Synthesis, and Biological Evaluation of Novel Stachydrine Derivatives as Potent Neuroprotective Agents for Cerebral Ischemic Stroke?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Liang Zhang; Feng Li; Chenhui Hou; Sifeng Zhu; Lili Zhong; Jianchun Zhao; Cai Song; Wenbao Li
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0028-1298)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)