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number of purified nuclear antigens are included in these tests. More importantly, there has been no comprehensive and organized study to compare these various methods with the fluorescent ANA test regarding sensitivity, specificity, and predictive values. The American College of Rheumatology (ACR) Antinuclear Antibody Task force recommends that IFA should remain as the gold standard for ANA testing. 5,6 An international group of experts recently published detailed recommendations for the assessment and interpretation of ANA and related autoantibodies. 2 IFA is the reference method for ANA screening and "alternative assays can be used while keeping in mind that the false negative and false positive ratio of these methods may be different." If the ANA is negative with an alternative assay in a patient highly suspected of SLE, the IFA test should be done. Clinical laboratories using a solid phase immunoassay or other alternative method should also provide data on request by the clinician on the sensitivity and specificity of the test system compared with IFA. 5,6 Table 46.1 shows evidence-based guidelines for the IFA test for ANA. 6 The ANA panel available in most clinical laboratori

Author

Francisco P. Quismorio; Anne V. Quismorio

Published

2019

Language

EN