About this Dentistry article
Salivary cytokine profiles in the immunocompetent individual with Candida ‐associated denture stomatitis by J. E. Leigh; C. Steele; F. Wormley; P. L. Fidel is a Dentistry article available to read on EtoBox.
Cell‐mediated immunity conferred by CD4^+^ T helper cells is considered the predominant host defense against mucosal __Candida__ infections, with Thelper (Th1)‐type responses associated with resistance to infection and Th2‐type responses associated with susceptibility to infection. Oropharyngeal candidiasis, the most common oral opportunistic infection in HIV‐infected persons, is associated with a Th2‐type cytokine profile in saliva. To obtain more direct evidence for a role of salivary cytokines in susceptibility to oropharyngeal candidiasis during immunosuppression, we evaluated Th1/Th2‐type cytokines in the saliva of those with denture stomatitis, a form of oropharyngeal candidiasis not related to immunosuppression. Results showed that HIV‐negative denture wearers with and without denture stomatitis demonstrated a mixed Th1/Th2 cytokine profile with no significant differences found between the groups. These results suggest that a local Th cytokine dichotomy in saliva is not associated with susceptibility to denture stomatitis in immunocompetent persons.
It is typically read by researchers, students, and practitioners in Dentistry.
- Author
- J. E. Leigh; C. Steele; F. Wormley; P. L. Fidel
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0055)
- Published
- 2002
- Language
- EN
- Field
- Dentistry (Health Sciences)