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The model proposes that overnutrition leads to increased lipid breakdown and insulin secretion by pancreatic beta cells, causing endoplasmic reticulum stress from high insulin production demands. This stress initially activates the unfolded protein response but over time becomes less effective, resulting in cell death. Prolonged insulin secretion also causes amyloid fibril formation from amylin that accumulates on beta cells and induces dysfunction and apoptosis.

Author

andiariansyah

Language

EN