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The study investigates the role of human AP-endonuclease 1 (APE1) in regulating KRAS expression in pancreatic ductal adenocarcinoma (PDAC) cells, highlighting APE1 as a G-quadruplex (G4) binding protein that promotes G4 formation. Loss of APE1 disrupts stable G4 structures and reduces KRAS expression, which is critical for the survival of PDAC cells, making APE1 a potential therapeutic target. Elevated levels of APE1 and G4 DNA in PDAC patient samples suggest their significance in cancer progression and tre

Author

jingyu.he.2004

Language

EN