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SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation by Noémi Nagy; Akihiko Maeda; Kentaro Bandobashi; Loránd L. Kis; Jun Nishikawa; Pankaj Trivedi; Alberto Faggioni; George Klein; Eva Klein is a Medicine article available to read on EtoBox.
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## Abstract The SH2 domain containing SH2D1A protein has been characterized in relation to the X‐linked lymphoproliferative disease (XLP), a primary immunodeficiency that leads to serious clinical conditions after Epstein‐Barr virus (EBV) infection. The SH2D1A gene is mutated in the majority of XLP patients. We previously detected SH2D1A in activated T and NK cells, but not in B lymphocytes. We have found SH2D1A protein in Burkitt lymphoma (BL) lines, but only in those that carried EBV and had a Group I (germinal center) phenotype. All the EBV‐carrying Group III (immunoblastic) and the EBV‐negative BL lines tested were SH2D1A‐negative. Motivated by these differences, we studied the impact of EBV and the cellular phenotype on SH2D1A expression. We approached the former question with BL sublines after both the loss of the virus and subsequent reinfection. We also tested original EBV‐negative BL lines carrying transfected EBV genes, such as EBNA1, EBNA2, EBNA6, EBER1, 2 and LMP1, respectively. In our experiments, no direct relationship could be seen between EBV and SH2D1A expression. We modified the phenotype of the Group I BL cells by LMP1 transfection or CD40 ligation. The phenotypi
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- Author
- Noémi Nagy; Akihiko Maeda; Kentaro Bandobashi; Loránd L. Kis; Jun Nishikawa; Pankaj Trivedi; Alberto Faggioni; George Klein; Eva Klein
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)