About this Biochemistry, Genetics and Molecular Biology article
Three Related Centromere Proteins Are Absent from the Inactive Centromere of a Stable Isodicentric Chromosome by William C. Earnshaw; Barbara R. Migeon is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
We developed an aqueous spreading procedure that permits simultaneous analysis of human chromosomes by Q-banding and indirect immunofluorescence. Using this methodology and anticentromere antibodies from an autoimmune patient we compared the active and inactive centromeres of an isodicentric X chromosome. We show that a family of structurally related human centromere proteins (CENP-A, CENP-B, and CENP-C) is detectable only at the active centromere. These antigens therefore may be regarded both as morphological and functional markers for active centromeres.
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- William C. Earnshaw; Barbara R. Migeon
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0009-5915)
- Published
- 1984
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)